- 中文名称
mGluR3 (胞外)抗体
- 英文名字
- mGluR3 (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1257
- 产品报价
- ￥4125/50 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- L-Glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptors family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and signal transduction.
Group II of the metabotropic glutamate receptors includes the mGluR2 and mGluR3 receptors.
The receptors present the typical G-protein coupled receptor (GPCR) signature topology: seven transmembrane domains with a large extracellular N-terminus domain that contains the glutamate binding site, and an intracellular C-terminus one.1,2
mGluR2 and mGluR3 are coupled to Gi/Go and hence inhibit cAMP formation following receptor activation.1, 2
mGluR3 is expressed in neurons and glia in many brain regions including cerebral cortex, hippocampus and brain stem. mGluR3 expression is predominantly presynaptic consistent with its role as an inhibitory autoreceptor, that is, activation of mGluR3 by glutamate inhibits additional glutamate release from the same neurons.1, 2
Several lines of evidence suggest that mGluR3 is important for long term depression, glial function and neuroprotection.
Some studies, though not all, have shown genetic association of mGluR3 gene polymorphisms with psychosis and with schizophrenia-related phenotypes. Based in these findings, mGluR3 has been suggested as a therapeutic target for both psychosis and schizophrenia.3
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope located at the extracellular N-terminus domain of the rat mGluR3 receptor. The epitope is specific for mGluR3 and will not cross-react with the closely related mGluR2 channel. Anti- mGluR3 (extracellular) antibody (#AG1257) can be used in Western blot analysis and immunohistochemical applications, and recognizes mGluR3 from rat and mouse samples.
- 应用类型
- WB
- 免疫原
- P31422
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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