- 中文名称
Glucagon-like Peptide 1 Receptor (胞外)抗体
- 英文名字
- Glucagon-like Peptide 1 Receptor (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1238
- 产品报价
- ￥4125/50 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- Glucagon-like peptide 1 (GLP-1) is a hormone secreted by the intestine following a meal1. This hormone is known to enhance the secretion of insulin, important to regulate glucose blood levels2,3. In pancreatic b-cells, other than stimulating insulin secretion, GLP-1 action is also important for b-cell mass expansion2.
GLP-1 exerts its biological functions through Glucagon-like peptide 1 receptor (GLP-1 receptor), a member of the G-protein coupled receptor superfamily. Like all members this receptor spans the membrane seven times. GLP-1 receptor couples with Gs, thereby stimulates adenylate cyclase which consequently leads to an increase in cAMP2.
The receptor is expressed in various tissues, namely the pancreas, adipose tissue, muscle, heart, gastrointestinal tract and liver. GLP-1 receptor is also found in the central nervous system where it provides a neuroprotective effect4.
The glucagon-like peptide 1 system may serve as a therapeutic treatment in diabetes mellitus, in order to maintain b-cell mass expansion2. In addition, the receptor may serve as a therapy target in various neurodegenerative diseases like Alzheimer’s and Parkinson’s disease4.
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat Glucagon-like peptide 1 receptor. Anti-Glucagon-like Peptide 1 Receptor (extracellular) antibody (#AG1238) can be used for western blot, immunohistochemical and immunocytochemical applications. It has been designed to recognize Glucagon-like peptide 1 receptor from human, rat and mouse samples.
- 应用类型
- WB
- 免疫原
- P32301
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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