- 中文名称
Ghrelin Receptor (胞外)抗体
- 英文名字
- Ghrelin Receptor (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1235
- 产品报价
- ￥4125/50 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- Ghrelin is a 28 amino acid peptide, acylated on a serine residue which is essential for its biological activity1,2. In rodents, an additional form of the peptide could be purified. The peptide is released from the stomach and exerts its effect to ghrelin receptor (GHS-R). GHS-R is a member of the G-protein coupled receptor (GPCR) superfamily. Like all members, the receptor has seven transmembrane spanning domains and upon activation it stimulates phospholipase C, thereby increasing IP3 and intracellular Ca2+ levels1,3.
GHS-R is expressed in the hypothalamus, pituitary and hippocampus1,3.
Some of the actions of ghrelin include the stimulation of growth hormone release, food intake, fat accumulation, regulation of memory and learning, activation of reward-related pathways and neuroprotection to name a few1,3.
GHS-R 1b is a truncated form of the full length receptor which is also expressed. Although its exact functions are unknown, it is believed that it may be involved in downregulating signaling from the full length receptor4. In addition, it is overexpressed in lung cancer where it dimerizes with neurotensin receptor4,5.
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat Ghrelin receptor. Anti-Ghrelin Receptor (extracellular) antibody (#AG1235) can be used in western blot and immunocytochemistry applications. It has been designed to recognize ghrelin receptor from human mouse and rat samples.
- 应用类型
- WB
- 免疫原
- O08725
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
