- 中文名称
H1 Histamine Receptor抗体
- 英文名字
- H1 Histamine Receptor Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1227
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from
L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1
The biological effects of histamine are mediated through four receptors (H1- H4 Histamine receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.
H1 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization.1
H1 receptors are expressed in many cell types including endothelial and smooth muscle cells where they mediate vasodilatation and increased vascular permeability effects.
H1 receptors are widely distributed through the brain where the mediate sleep-wake cycles and regulate cognitive functions.
H1 receptors are expressed in a several cell populations involved in the immune response, including T-cells and B-cells, monocytes and eosinophiles. 2,3
H1 anti-histamine compounds have been available for almost thirty years and are among the most commonly used medication for conditions such as allergic inflammation. In addition, H1 anti-histamines are also prescribed for the treatment of insomnia and analgesia.2, 3
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope located at the intracellular 3rd loop of the rat H1 Histamine receptor. Anti-H1 Histamine Receptor antibody (#AG1227) can be used in Western blot analysis and immunohistochemical applications, and recognizes H1 Histamine receptor from rat, mouse and human samples.
- 应用类型
- WB
- 免疫原
- P31390
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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