- 中文名称
人H4 Histamine Receptor (胞外)抗体
- 英文名字
- Human H4 Histamine Receptor (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1224
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1
The biological effects of histamine are mediated through four receptors (H1- H4 Histamine receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.
H4 Histamine Receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, mobilisation of calcium from intracellular stores and activation of the mitogen-activated protein kinase (MAPK) cascade. 1, 2
H4 Histamine Receptor is largely expressed in haemopoietic cells including mast cells, eosinophils, dendritic cells and T lymphocytes. H4 Histamine Receptors modulate eosinophil migration and the selective recruitment of mast cells leading to amplification of histamine-mediated immune responses. In addition, H4 Histamine Receptors are involved in dendritic cell activation and the regulation of T lymphocyte cytokine production.2, 3
These studies indicate that H4 Histamine Receptor is an attractive therapeutic target for the treatment of inflammatory disorders, such as allergy, asthma, chronic pruritus and autoimmune diseases.2, 3
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope located at the extracellular 1st loop of the human H4 Histamine receptor. Anti-Human H4 Histamine Receptor (extracellular) antibody (#AG1224) can be used in western blot and indirect flow cytometry applications, and recognizes H4 Histamine receptor from human samples.
- 应用类型
- FC
- 免疫原
- Q9H3N8
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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