- 中文名称
人BLT1 (胞外)抗体
- 英文名字
- Human BLT1 (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1223
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Leukotrienes (LTs) are lipid mediators prominently exerting proinflammatory responses. They are divided in two classes: cysteinyl LTs (cysLTs) which have a thioester linkage and LTB41. LTB4, a chemoattractant plays a prominent role in the recruitment and activation of leukocytes2.
LTB4 acts through two receptors which belong to the G-protein coupled receptor superfamily: BLT1 and BLT2. BLT1 displays high affinity for LTB4 and is highly expressed in leukocytes including granulocytes, macrophages, mast cells, dendritic cells and effector T cells3 and is expressed to much lower levels in spleen, thymus, heart, skeletal muscle brain and liver2-4. BLT2 on the other hand is a low affinity receptor which does not display selectivity towards LTB45. Its expression is much more ubiquitous than that of BLT1. It is expressed in most human tissues, with the highest expression being in spleen, liver, ovary, and leukocytes2,5-8. The two receptors could couple and activate different G-proteins, depending on the cell type and the cellular events activating the receptors2. However, activation of BLT1 ususally correlates with increasing intracellular concentrations of Ca2+.
The LTB4/BLT1 system is involved in many allergic reactions as well as asthma induced as an allergic response, where it plays a significant role in recruiting neutrophils and effector T cells into lungs, as part of an inflammatory response induced by allergens1.
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of human BLT1. Anti-Human BLT1 (extracellular) antibody (#AG1223) can be used for Western blot analysis and indirect flow cytometry applications. It has been designed to recognize BLT1 from human samples only.
- 应用类型
- WB
- 免疫原
- Q15722
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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