- 中文名称
Neuropeptide Y4 Receptor抗体
- 英文名字
- Neuropeptide Y4 Receptor Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1187
- 产品报价
- ￥4125/50 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1 It belongs to the NPY family, along with peptide YY (PYY) and pancreatic polypeptide (PP). NPY is involved in the regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2
NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R), and Y6 (NPY6R).2 Four of these (Y1, Y2, Y4, and Y5) are expressed in humans.2
The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.
Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.3 Based on their high frequency and density in steroid hormone-producing tumors, the NPYRs might be of potential use in tumor management.2
NPY4R preferentially binds PP, while NPY1R, NPY2R, and NPY5R bind both NPY and PP.
NPY1R, NPY2R, and NPY5R share a low degree of identity (27–31% overall). NPY4R is more similar to NPY1R, displaying an overall identity of 43–53%.4
Human NPY4R (also named pancreatic polypeptide receptor 1) mRNA is highly expressed in the small and large intestines and the prostate. Tissue distribution studies in human and mouse suggest potential roles for NPY4R in the gastrointestinal tract, heart, and prostate, as well as in neural and endocrine signaling. Only low levels of NPY4R expression in various areas of brain were displayed.5
Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of the rat Neuropeptide Y4 receptor (NPY4R). The Anti-Neuropeptide Y4 Receptor antibody (#AG1187) can be used for Western blot analysis and immunocytochemical applications and should recognize NPY4R from human, rat, and mouse samples.
- 应用类型
- WB
- 免疫原
- Q63447
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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