- 中文名称
Na+/H+ Exchanger 1 (NHE-1) (胞外)抗体
- 英文名字
- Na+/H+ Exchanger 1 (NHE-1) (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1160
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- In order to function in optimal conditions, cells must maintain a close to neutral intracellular pH. They have adopted various mechanisms in order to do so, one of which is via Na+/H+ exchangers (NHEs). Genes belonging to this group are expressed along a very broad range of organisms and are essential for protecting cells against intracellular acidification1.
To date, nine genes have been identified in mammals; NHE1-9. These membrane proteins have 10-12 transmembrane domains depending on whether a splice variant is expressed and an intracellular N-terminal. The C-terminal domain can be either intracellular or extracellular, also depending whether a splice variant of the protein is involved. The C-terminal part of the protein also undergoes posttranslational modification such as phosphorylation2. Both NHE-1 and NHE-2 have an extracellular loop which is glycosylated1,3,4.
Under physiological conditions, the Na+/H+ exchanger mediates the exchange of one extracellular Na+ ion for one intracellular proton, thereby keeping the overall charge neutral1. The extracellular binding site of Na+ is not selective as it can also bind Li+ and H+ 1,5,6. K+ ions inhibit NHE-1 but have no effect on NHE-27. The activation of NHE-1 and NHE-2 is sensitive to intracellular acidic pH. Under physiological conditions, both exchangers are not active and upon a drop of intracellular pH, they are rapidly activated1,5,8.
NHE-1 expression is ubiquitous and may serve as a housekeeping gene9.
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat NHE-1. Anti-Na+/H+ Exchanger 1 (NHE-1) antibody (#AG1160) can be used in western blot immunocytochemistry and indirect flow cytometry applications. It has been designed to recognize NHE-1 from human, rat and mouse samples.
- 应用类型
- WB
- 免疫原
- P26431
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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