In 1999, three gene families that encode minK-related peptides (MiRPs) were identified (known also as IsK-related auxiliary subunits). These MiRPs, along with minK, constitute four KCNE families (KCNE1 to KCNE4, encoding minK and MiRP1 to MiRP3).1
MiRP1 mutations that are linked to congenital (LQT6) or acquired LQT syndrome have been identified. However, currently there is no biochemical evidence supporting an association between native MiRP1 and hERG proteins in cardiac myocytes.2 MiRP2 has been shown to decrease the single channel conductance and accelerates the rate of HERG channel deactivation3 and to suppress the expression of hERG in oocytes.
