- 中文名称
Kir2.1抗体
- 英文名字
- Kir2.1 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1138
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 产品新闻
- 背景资料
Kir2.1 is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.1
The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heterotetramers.
Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis.
Kir2.1 is a member of the Kir2.x subfamily that includes four members (Kir2.1- Kir2.4) that are characterized by strong inward rectification and high constitutive activity.
Kir2.1 is expressed in a variety of tissues including heart, brain, vascular smooth muscle cells and skeletal muscles.
In heart, Kir2.1 is a molecular component of the IK1 current that is responsible for setting the resting membrane potential, preventing membrane hyperpolarization due to Na+ pump activity, influencing propagation velocity, altering the electrical space constant, and promoting late phase repolarization.2 In fact, mutations in Kir2.1 channels have been linked to a form of long QT syndrome (LQT7) known as Andersen's syndrome that is characterized by cardiac arrhythmias, periodic paralysis, and dysmorphic features.3
- 应用类型
- WB
- 免疫原
- P48049
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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