- 中文名称
K2P9.1 (TASK-3)抗体
- 英文名字
- K2P9.1 (TASK-3) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1127
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 产品新闻
- 背景资料
- K2P9.1 (also named TASK3 or KCNK9) is a member of the 2-pore (2P) domain K+ channels family that probably assemble as dimers to constitute a functional channel.1 These channels show little time or voltage dependence and are considered to be “leak” or “background” K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.
The channels are regulated by diverse physical and chemical stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, etc.2 The physiological role of the K2P channels is not yet clear, though they were proposed to participate in breathing, aldosterone secretion and anesthetic-mediated neuronal activity.
In human, expression of K2P9.1 is restricted in brain and its expression overlaps with the structurally related K2P3.1 (TASK1, KCNK3) channel. In rat, it is more widely expressed in other tissues as well as in brain.
Unexpectedly, K2P9.1 was found to be over-expressed between 5 to 100-fold in 44% of breast cancer tumors tested.
Transfection and over-expression of K2P9.1 in cell lines promotes tumor growth and confers resistance to hypoxia and serum deprivation.3 Recently, K2P9.1 was found to play an important role in K+-dependent apoptosis of cerebellar granules.4
Alomone Labs is pleased to present a new polyclonal antibody to Anti-K2P9.1 (TASK3).
The antibody was raised against an epitope corresponding to residues 57-73 of the rat K2P9.1 protein. The chosen epitope is located in the extracellular region near to the Pore 1 loop, and shares 15 out of 17 residues with the human isoform.
Reactivity of the antibody was confirmed by Western blotting in both rat and human samples.
- 应用类型
- WB
- 免疫原
- Q9ES08
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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