- 中文名称
K2P2.1 (TREK-1)抗体
- 英文名字
- K2P2.1 (TREK-1) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1125
- 产品报价
- ￥4125/50 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- K2P2.1 (also named TWIK-Related K+ channel, TREK-1 or KCNK2) is a member of the 2-pore (2P) domain K+ channels family that includes at least 16 members. These channels show little time or voltage dependence and are considered to be “leak” or “background” K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.
The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini.
K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators. K2P2.1 can be integrated to a K2P subfamily that includes K2P4.1 (TRAAK) and K2P10.1 (TREK2) that are activated by intracellular unsaturated fatty acids such as arachidonic acid, lysophosphatidic acid and mechanical stretch. In addition, K2P2.1 can also be activated by general anesthetics such as halothane and chloroform and intracellular acidification.
K2P2.1 expression in humans is largely restricted to the brain with some expression in ovary and small intestine while K2P2.1expression in rodents is more widespread.
K2P2.1 has an important role in mood regulation, as knockout mice show resistance to depression, suggesting that K2P2.1 may be a potential target for anti-depressants.
K2P2.1 is involved in the fast release of glutamate from astrocytes. It requires the activation of Gαi, dissociation of Gβγ, followed by the opening of the glutamate permeable K2P2.1 (TREK-1) K+ channel through its interaction with Gβγ. For this purpose, TREK-1 is localized at the cell surface of the cell body and processes of astrocytes.
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of human K2P2.1. Anti-K2P2.1 (TREK-1) antibody (#AG1125) can be used in western blot analysis, and has been designed to recognize TREK-1 channel from mouse, rat and human samples.
- 应用类型
- WB
- 免疫原
- O95069
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
