- 中文名称
HCN3抗体
- 英文名字
- HCN3 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1118
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Hyperpolarization-activated cation currents (Ih) appear in the heart and the brain and play a crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity.1,2
The Ih currents are generated by the Hyperpolarization-activated Cyclic Nucleotide-gated cannel family (HCN), which comprises of four homologous members, named HCN1-4. Each HCN subunit consist of six transmembrane domains (TM), a pore region between TM5-TM6 and a binding domain to cyclic nucleotides (CNBD) in the cytoplasmic C-terminus.2
The HCN subunits can form functional homomers and can also co-assemble into functionally heteromers.2
The channels are closely related to each other and share homology of about 60%. However, they differ from each other in their cytoplasmic N- and the C-terminus. HCN1-4 mainly differ from each other with regard to their speed of activation and the extent by which they are modulated by cAMP. HCN1 is the fastest channel, followed by HCN2, HCN3 and HCN4.2,3
The HCN3 channels are abundant in the brain where high expression of HCN3 mRNA was found in the hypothalamus.
Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of the HCN3 channel. The Anti-HCN3 (#AG1118) can be used for Western Blotting and Immunohistochemical applications. It has been designed to recognize HCN3 from human, rat and mouse samples.
- 应用类型
- WB
- 免疫原
- Q9JKA8
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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