- 中文名称
CNGA3抗体
- 英文名字
- CNGA3 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1116
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Cyclic nucleotides are important second messengers in many cellular functions such as visual transduction, and relaxation of smooth muscle cells. Cyclic nucleotides exert their cellular functions through three major classes of cellular receptors, one of them is the cyclic nucleotide-gated (CNG) channels.1 The CNG channels are non-selective cation channels facilitating the influx of Na+ and Ca2+ ions, following activation by intracellular cyclic nucleotides.2 In vertebrates, six members of the CNG channel family were identified and grouped according to sequence homology into two subtypes, CNGA and CNGB. The native CNG channels are composed of a and b subunits in a tetrameric configuration. To date, four types of the a subunits (CNGA1-4) and two b subunits (CNGB1, CNGB3) have been characterized.3-4
Each subunit contains 6 TM domains and intracellular cAMP or cGMP binding domains but, are also modulated by other factors including phosphorylation and calmodulin.5 In a heterologous expression system, only the a subunits are capable of forming functional homomeric channels.
CNG ion channels are essential in visual and olfactory signal transduction. The CNGA3 channel is primarily expressed in cone photoreceptors where it participates in light transduction (daylight and color vision). CNG channels expression was also found in the hippocampus, cortex, Purkinje cells and other neural derived tissues. CNGA3 was also detected in kidney, heart, brain and sperm, where it was thought to have an important role in the control of sperm motility and fertility. However, CNGA3-deficient mice were shown to be as fertile and produce at normal rate as wild types.6
Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of rat CNGA3. The Anti-CNGA3 antibody (#AG1116) can be used for western blot and immunohistochemical applications. It has been designed to recognize CNGA3 from rat and mouse samples.
- 应用类型
- WB
- 免疫原
- Q9QWN7
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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