- 中文名称
KV10.1 (EAG-1)抗体
- 英文名字
- KV10.1 (EAG-1) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1105
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- KV10.1 is a member of the Ether-a-go-go family of voltage-activated K+ channels. To date, the family includes 8 members: the closely related KV10.2 (EAG-2) protein, the KV12 (elk) subfamily (elk1, elk2, elk3) and the KV11 (erg) proteins (erg1, erg2, erg3). As with the other KV superfamily members, KV10.1 shows the characteristic 6 transmembrane domains with intracelullar N and C termini.
The KV10 subfamily current is characterized by outward rectification without inactivation and slow activation kinetics. Its expression is normally confined to the brain where its physiological function has not yet been clarified.
Intriguingly, the KV10.1 channel has been implicated in malignant tumor development. It has been shown that KV10.1 was inappropriately expressed in several cancer cell lines. Moreover, one study showed that KV10.1 by itself had oncogenic potential, as a cell line transfected with the channel, induced aggressive and faster tumor growth in vivo as compared to a cell line transfected with an unrelated KV channel.
Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of rat Kv10.1. The Anti-Kv10.1 (EAG-1) antibody (#AG1105) can be used for western blot , immunohistochemical and immunocytochemical applications. It has been designed to recognize Kv10.1 from rat, human and mouse samples. The antibody is specific for KV10.1 and it will not crossreact with KV10.2.
- 应用类型
- WB
- 免疫原
- Q63472
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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