The P2X3 receptor belongs to the ligand-gated ion channel P2X family, that consists of seven receptor subtypes named P2X1-P2X7 and is activated by extracellular ATP 1-3.
All P2X subunits, with the exception of P2X6, can assemble to form homomeric or heteromeric functional channels4,5. The different P2X receptors show distinct expression patterns. P2X1-6 has been found in the central and peripheral nervous system, while the P2X7 receptor is predominantly found in cells of the immune system. The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals6,7. Involvement of ATP in the mechanism of chronic pain has been also suggested7,8. P2X3 receptor is now becoming a possible target for the development of pain therapeutics.
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat P2X3 receptor. Anti-P2X3 Receptor (extracellular) antibody (#AG1060) can be used in western blot immunohistochemical and immunocytochemical applications. It has been designed to recognize P2X3 receptor from rat, mouse, and human samples.
