- 中文名称
Caspr2抗体
- 英文名字
- Caspr2 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1050
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Contactin-associated protein 2 (Caspr2) is a member of the neurexin superfamily, a group of transmembrane proteins that mediate cell–cell interactions in the nervous system1,2.
Neurexins are adhesion molecules expressed mainly at presynaptic locations that form trans-synaptic cell – cell adhesion complexes via binding to their postsynaptic partners the neuroligins2.
Caspr2, like other neurexin proteins, is a type I membrane protein that contains epidermal growth factor repeats, laminin G domains, an F5/8 type C domain, and fibrinogen-like domains in its extracellular domain1,2.
Caspr2 is localized at the juxtaparanodes of myelinated axons, a specialized region that mediates interactions between neurons and glia during nervous system development1.
The juxtaparanodal region is highly enriched with heteromultimers of the K+ channels Kv1.1, Kv1.2, and their cytoplasmic Kvß2 subunit, which may help in axon conduction stabilization and the maintenance of the internodal resting potential1. Caspr2 is essential for the targeted localization of these channels in the juxtaparanodal regions. Indeed, targeted disruption of Caspr2 resulted in a marked reduction in the accumulation of K+ channels at the juxtaparanodes in both peripheral and central nervous system axons3.
Moreover, mutations in the Caspr2 gene have been implicated in multiple neurodevelopmental disorders, including Tourette syndrome, schizophrenia, epilepsy, autism, attention-deficit hyperactivity disorder and mental retardation4-6.
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope located at the intracellular C-terminal domain of human Caspr2. Anti-Caspr2 antibody (#AG1050) can be used in Western blot applications, and was designed to recognize Caspr2 from rat, mouse and human samples.
- 应用类型
- WB
- 免疫原
- Q9UHC6
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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