- 中文名称
5-Hydroxytryptamine Receptor 1D (胞外)抗体
- 英文名字
- 5-Hydroxytryptamine Receptor 1D (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1010
- 产品报价
- ￥4125/50 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- Serotonin (5-hydroxytryptamine, 5-HT) plays unequivocally a most important role in the normal physiology amongst higher eukaryotes, as do most neurotransmitters. The physiological roles of serotonin and its receptors range from appetite, regulation of the circadian rhythm, sexual behavior, memory and nociception.
Serotonin is also involved in migraine and some psychiatric diseases such as depression anxiety and aggression1. Serotonin and its receptors also have an influence on the cardiovascular, pulmonary, gastrointestinal (GI) and genitourinary systems2.
To date, some fifteen serotonin receptors have been cloned and grouped into seven families (5-HT1-5-HT7) based on their signaling mechanisms. The 5-HT1 receptor class comprises 5 different receptors with ranging homology. Apart from 5-HT3, all serotonin receptors belong to the G-Protein Coupled Receptor superfamily and therefore span the membrane seven times3.
Members of 5-HT1 receptor class all couple Gi/0 thereby inhibiting adenylate cyclase.
In the central nervous system, 5-HT1D is expressed in the basal ganglia, hippocampus and cortex in rat and in the basal ganglia, midbrain and spinal cord in human. In serotonin neurons, 5-HT1D receptors are autoreceptors thereby inhibiting the release of 5-HT. In GABA, ACh, and glutamate neurons they are heteroreceptors where they control the release of these neurotransmitters4,5.
As mentioned above, the serotonin system plays an undeniable role in the perception and processing of pain. Indeed, many migraine sufferers are prescribed triptan-based drugs which activate 5-HT1B and 5-HT1D receptors2.
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat 5-Hydroxytryptamine Receptor 1D (5-HT1D). Anti-5-Hydroxytryptamine Receptor 1D (extracellular) antibody (#AG1010) can be used in western blot analysis. It has been designed to recognize 5-Hydroxytryptamine Receptor 1D from human, rat and mouse samples.
- 应用类型
- WB
- 免疫原
- P28565
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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