AKR1A1 (aldo-keto reductase family 1 member A1), also known as ALR (aldehyde reductase), DD3 (dihydrodiol dehydrogenase 3) or ALDR1 (alcohol dehydrogenase), is a widely and abundantly expressed member of the aldo-keto reductase (AKR) family of proteins. Members of the AKR family are soluble NADPH-dependent oxidoreductases. They play important roles in the metabolism of drugs, carcinogens and reactive aldehydes. AKR1A1 exists as a monomer and catalyzes the reduction of xenobiotic and biogenic aldehydes and ketones to their corresponding alcohols. In particular, AKR1A1 efficiently catalyzes medium-chain and aromatic aldehydes. AKR1A1 participates in the biosynthetic pathways of cholesterol and triglyceride and plays a role in the activation of polycyclic aromatic hydrocarbons (PAHs).
