Stress-activated serine/threonine-protein kinase involved in cytokines production， endocytosis， reorganization of the cytoskeleton， cell migration， cell cycle control， chromatin remodeling， DNA damage response and transcriptional regulation。 Following stress， it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14， leading to phosphorylation of substrates。 Phosphorylates serine in the peptide sequence， Hyd-X-R-X(2)-S， where Hyd is a large hydrophobic residue。 Phosphorylates ALOX5， CDC25B， CDC25C， ELAVL1， HNRNPA0， HSF1， HSP27/HSPB1， KRT18， KRT20， LIMK1， LSP1， PABPC1， PARN， PDE4A， RCSD1， RPS6KA3， TAB3 and TTP/ZFP36。
应用类型
IP， WB (1:500 colorimetric， 1:500 ECL)
免疫原
Synthetic peptide corresponding to a portion of human MAPKAPK-2. The sequence is completely conserved in mouse， hamster and rabbit.
