Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury。 Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site。 Can activate neuronal death in response to stress。 Regulates dendritic arborization through the MAPK4-JNK pathway。 Involved in innate immune response。 Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1， TRIF-dependent activation of NF-kappa-B and IRF3， and the phosphorylation of MAPK14/p38。
