May function as an inducer of apoptosis。 Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling。 Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65。 Also inhibits transcriptional activity of RELA。 Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18。
应用类型
ICC (1:100)， WB (1:1000)
免疫原
Recombinant human NLRP3/NALP3 (NACHT-， LRR- and PYD-containing protein 3) (pyrin domain).
