Essential for necroptosis， a programmed cell death process in response to death-inducing TNF-alpha family members。 Upon induction of necrosis， RIPK3 interacts with， and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex。 RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL， GLUD1， and PYGL。 These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation， which could result in enhanced ROS production。
应用类型
WB
免疫原
Recombinant human RIP3 (receptor-interacting protein 3)
