Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy， as well as in mitophagy。 Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3， and downstream of the ULK1 and PI3-kinase complexes。 Involved in xenophagy of Staphylococcus aureus。 Invading S。aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation。 Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation， a process that is distinct from starvation-induced autophagy。 May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor（MPR) recycling pathway。
应用类型
WB (1:1000)
免疫原
Synthetic peptide corresponding to aa of C-terminal human WIPI-1.
