Accelerates programmed cell death by binding to， and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein。 Under stress conditions， undergoes a conformation change that causes translocation to the mitochondrion membrane， leading to the release of cytochrome c that then triggers apoptosis。 Promotes activation of CASP3， and thereby apoptosis。
应用类型
WB (1:1000， ECL)
免疫原
Synthetic peptide corresponding to a portion of human BAX.
