Erlotinib （Item No. 10483） is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor （EGFR）， inhibiting EGFR-associated kinase activity （IC50 = 2.5 uM）. It binds to the EGF-activated receptor， with the phenyl group at one end sequestered in a hydrophobic pocket of the kinase domain and the ether linkages at the opposite end projecting into solvent. 4-methyl Erlotinib is an analog of erlotinib characterized by the addition of a methyl group at the four position of the phenyl group. The biochemical and physiological properties of this compound are not known.
产品描述
An erlotinib analog characterized by the addition of a methyl group at the four position of the phenyl group
