Prostaglandin D2 ethanolamide （PGD2-EA）-d4 contains four deuterium atoms. It is intended for use as an internal standard for the quantification of PGD2-EA by GC- or LC-mass spectrometry. PGD2-EA is a bioactive lipid produced by the sequential metabolism of anandamide （arachidonoyl ethanolamide） by cyclooxygenase （COX） enzymes， in particular by COX-2， and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors， including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons， an effect which is the opposite of that induced by anandamide.. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.
产品描述
An internal standard for the quantification of PGD2-EA by GC- or LC-MS
