.omega.-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. .omega.-3 fatty acids are now known to be essential for infant growth and development and protect against heart disease, thrombosis, hypertension, and inflammatory and autoimmune disorders. In human platelet membranes, .omega.-3 arachidonic acid inhibits arachidonoyl-CoA synthetase with a Ki of 14 uM. It also inhibits arachidonoyl-CoA synthetase in calf brain extracts with an IC50 value of about 5 uM.
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.omega.-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. .omega.-3 fatty acids are now known to be essential for infant growth and development and protect against heart disease, thrombosis, hypertension, and inflammatory and autoimmune disorders.{5525} In human platelet membranes, .omega.-3 arachidonic acid inhibits arachidonoyl-CoA synthetase with a Ki of 14 uM. It also inhibits arachidonoyl-CoA synthetase in calf brain extracts with an IC50 value of about 5 uM.{2166}