4-hydroxy Nonenal Glutathione-d3 （4-HNE-GSH-d3 （trifluoroacetate salt） contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE-GSH （trifluoroacetate salt） by GC- or LC-mass spectrometry. 4-hydroxy-Nonenal （4-HNE） is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids， such as arachidonic acid and linoleic acid. 4-HNE-GSH is a major adduct formed by the reaction of 4-HNE with GSH. 4-HNE-GSH levels in liver， plasma， or isolated cells can serve as biomarkers for oxidative stress. The trapping of 4-HNE by glutathione to give HNE-GSH prevents the formation of DNA adducts with 4-HNE. In human polymorphonuclear leukocytes， HNE-GSH is metabolized to 1，4-dihydroxynonene glutathione （DHN-GSH）， 4-hydroxynonenoic acid glutathione （HNA-GSH）， and 4-hydroxy nonenal mercapturic acid （HNE-MA）.
产品描述
An internal standard for the quantification of 4-HNE-GSH （trifluoroacetate salt） by GC- or LC-MS
