Phosphatidyl inositol trisphosphate （PtdIns-（3，4，5）-P3） is a membrane phospholipid that may be cleaved by phospholipase C （PLC） to produce the second messengers inositol tetrakisphosphate （IP4） and diacylglycerol （DAG）. IP4 triggers an increase in intracellular calcium. PtdIns-（3，4，5）-P3 （1-stearoyl， 2-docosahexaenoyl） is an uncommon phospholipid having the ω-3 fatty acid docosahexaenoate （DHA） in the sn-2 position. In addition to releasing an unusual DHA-containing DAG in response to PLC， this phospholipid can serve as a source of DHA in response to phospholipases A2 （PLA2）. Importantly， the inositol head group of PtdIns-（3，4，5）-P3 can serve as an anchor for the binding of proteins bearing pleckstrin homology （PH） domains.
产品描述
An uncommon phospholipid having the ω-3 fatty acid docosahexaenoate （DHA） in the sn-2 position； releases an unusual DHA-containing DAG in response to PLC and can serve as a source of DHA in response to PLA2； can serve as an anchor for the binding of proteins bearing pleckstrin homology domains
