Eicosapentaenoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin （Item No. 70665）. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase （FAAH） and the transient receptor potential vanilloid-type 1 （TRPV1） channel， reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with eicosapentaenoic acid have not been studied. However， replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation （IC50 = 0.76 uM） without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamide （IC50 > 50 uM）.
产品描述
A hybrid molecule patterned after arachidonoyl serotonin； the biological effects of eicosapentaenoyl serotonin are unknown
