Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin (Catalog No. 70665). Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50 = 0.76 uM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 uM).
产品描述
A hybrid molecule patterned after arachidonoyl serotonin; while saturated 11- or 12-fatty acids linked to serotonin potently inhibit capsaicin-induced TRPV1 channel activation (IC50 =0.76 uM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 uM), the effects of stearoyl serotonin are unknown