CEP-Lysine-d4 contains four deuterium atoms at the carboxyethyl 2，3’，3，3’ positions. It is intended for use as an internal standard for the quantification of CEP-lysine by GC- or LC-mass spectrometry （MS）. Docosahexaenoic acid （DHA） is an ω-3 polyunsaturated fatty acid that is abundant in the brain and in photoreceptor cell membranes in the retina. Oxidative cleavage of phospholipids containing DHA produces reactive electophilic phospholipid fragments， including 4-hydroxy-7-oxohept-5-enoates. These can interact with the primary amine group of lysyl residues to produce 2-（ω-carboxyethyl）pyrrole （CEP） derivatives， which are abundant in certain diseases. Advanced glycation end products， including CEP-lysine are biomarkers for age-related macular degeneration.（18413，18415} CEP-lysine-d4 is a deuterated form of CEP-lysine.
产品描述
An internal standard for the quantification of CEP-Lysine by GC- or LC-MS
