4-hydroxy Nonenal mercapturic acid-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE mercapturic acid by GC- or LC-mass spectrometry. Peroxidation of common .omega.-6 polyunsaturated fatty acids （PUFAs） such as linoleic acid， DGLA， and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine， primarily in the form of mercapturic acid conjugates. The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form .gamma.-lactols and .gamma.-lactones， respectively， producing at least four or five end urinary metabolites of 4-HNE in vivo.
产品描述
An internal standard for the quantification of 4-HNE mercapturic acid by GC- or LC-MS
