中文名称

(S)-(-)-Acenocoumarol (25 mg)

英文名字

(S)-(-)-Acenocoumarin|(S)-(-)-Nicoumalone, (S)-(-)-Acenocoumarol, 4-hydroxy-3-[(1S)-1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one

供应商

Cayman

产品货号

9000337-25

产品报价

￥33082/25 mg

产品说明书

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购买方式

产品新闻

背景资料

Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (S)-(-)-Acenocoumarol has a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-(+)-enantiomer (6.6 hours, 1.9 L/hour). The S-enantiomer undergoes extensive first-pass metabolism during absorption from the gastrointestinal tract, whereas (R)-(+)-acenocoumarol is rapidly absorbed and provides essentially complete oral bioavailability. Perhaps related to these pharmacokinetic characteristics, (S)-(-)-acenocoumarol is less potent in vivo as an anti-coagulant than the (R)-(+)-enantiomer. As the clearance of acenocoumarol is ~20-fold faster than that for warfarin, the plasma concentrations of acenocoumarol are substantially lower than those for warfarin in patients receiving long-term treatment.

产品描述

An enantiomer of the short-lived oral anti-coagulant acenocoumarol with a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-(+)-enantiomer (6.6 hours, 1.9 L/hour); undergoes extensive first-pass metabolism during absorption from the gastrointestinal tract; less potent in vivo than the (R)-(+)-enantiomer

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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