13，14-dihydro Prostaglandin E1-d4 （13，14-dh PGE1-d4） contains four deuterium atoms at the 3， 3’， 4， and 4’ positions. It is intended for use as an internal standard for the quantification of 13，14-dh PGE1 by GC- or LC-mass spectrometry. 13，14-dh PGE1 is an inhibitor of ADP-induced platelet aggregation in human platelet-rich plasma and washed platelets with IC50 values of 31 and 21 nM， respectively. 13，14-dh PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 of 40 nM. Also， 13，14-dh PGE1 activates adenylate cyclase in NCB-20 hybrid cells with a Kact of 668 nM.
产品描述
13，14-dh PGE1-d4 contains four deuterium atoms at the 3， 3’， 4， and 4’ positions. It is intended for use as an internal standard for the quantification of 13，14-dh PGE1 by GC- or LC-mass spectrometry.
