Prostaglandin A2 （PGA2） is a naturally occurring PG in gorgonian corals where it may function in self defense. At a 25 uM concentration， PGA2 blocks the cell cycle progression of NIH 3T3 cells at G1 and G2/M by preventing activation of cyclin-dependent kinases. At similar concentrations， it stabilizes transcripts for the tumor suppressor SMAR1， downregulating cyclin D1 expression. PGA2 also induces apoptosis in HL-60 cells. Prostaglandin A2 methyl ester is a lipophilic analog of PGA2 which may be more amenable for certain formulations or applications. Its biological properties have not been evaluated.
产品描述
A lipophilic analog of PGA2 which may be more suitable for certain formulations or applications
