- 中文名称
【干冰】Anti-Ubiquitin Hydrolase (UCHL1) (Mouse) Monoclonal Antibody - 900-301-E52
- 英文名字
- 【干冰】Anti-Ubiquitin Hydrolase (UCHL1) (Mouse) Monoclonal Antibody - 900-301-E52
- 供应商
- Rockland
- 产品货号
- 900-301-E52
- 产品报价
- ￥询价/100uL
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- UCHL1 antibody recognizes Ubiquitin C-terminal hydrolase 1 (UCHL1) which is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.nTherefore, UCHL1 monoclonal antibody is ideal for investigators involved in Neuroscience.
- 应用类型
- ELISA,IF Microscopy,Western Blot,
- 免疫原
- Anti-UCHL1 Monoclonal Antibody was produced in mouse by repeated immunizations with recombinant full length human UCHL1 extensively purified from E. coli.
- 来源宿主
- Mouse
- 反应性
- Bovine (Bos Taurus); H. sapiens (Human); Mus musculus (Mouse); Rattus (Rat)
- 保存建议
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
- 其他
- Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。
- 注意
-
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