The liver X receptors （LXRα and LXRβ） are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase， the rate limiting enzyme of classic bile acid synthesis. 22（R）-hydroxy Cholesterol is an endogenous agonist for LXRs that activates LXRα with an EC50 value of 325 nM. 22（R）-hydroxy Cholesterol， acting through LXR heterodimerized with the retinoid X receptor， induces the expression of the ABCA1 reverse cholesterol transporter. This activity increases the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol. 22（R）-hydroxy Cholesterol can be used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists which have potential as therapeutic agents for the treatment of atherosclerosis.
产品描述
An endogenous agonist for LXRα （EC50 = 325 nM） that can induce the expression of the ABCA1 reverse cholesterol transporter to inhibit the overall absorption of cholesterol； used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists
