- 中文名称
【Pim 1】Pim 1蛋白，有活性的（5 ug）
- 英文名字
- Pim 1, Active
- 供应商
- Biovision
- 产品货号
- 7742-5
- 产品报价
- ￥已停产
- 产品说明书
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- 产品新闻
- 背景资料
- The proto-oncogene Pim1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from Moloney murine leukemia virus induced T-cell lymphomas in mice, Pim1 is involved in the control of cytokine-mediated cell proliferation, differentiation and survival of lymphoid and myeloid cells as well as others. Expression of Pim1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Accumulating data support that the expression of Pim1 is mediated through activation of the JAK/STAT pathway. Some of the substrates of Pim1 include p21 Cip1, nuclear mitotic appartus protein, PTP-U2S and Socs-1. Recently, Pim1 has been shown to enhance the activities of p100, c-Myb and Cdc 25a and in part this might explain reported effects of Pim1 on mitogenesis. Pim1 interacts with c-Myb via the DNA binding domain and regulates its transcriptional activity.
- 序列
- Pim 1蛋白,有活性的蛋白产品，又称Pim, Serine/threonine-protein kinase Pim-1.其对应NCBI基因号为5595，NCBI基因别称为ERK1源，对应Accession号为P27361.该蛋白产品又称pim1, pim-1, Active Pim 1, Pim 1, Pim, human Pim, active kinase, active kinases, recombinant Pim 1, recombinant Pim, kinase activity assay, protein kinase等.
- 来源宿主
- 提供的【Pim 1】Pim 1蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.
- 溶解建议
- 提供的Pim 1蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.
- 保存建议
- 在您收到艾美捷发出的【Pim 1】Pim 1蛋白,有活性的产品后，建议将其置于-80°C保存.
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的Leader，BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供优质、新的细胞生物学研究工具而不断扩大产品及服务质量.
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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