中文名称

【CK2a1】CK2a1蛋白，有活性的（5 ug）

英文名字

CK2a1, Active

供应商

Biovision

产品货号

7738-5

产品报价

￥已停产

产品说明书

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产品新闻

背景资料

CK2 α (also termed casein kinase II α) is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lympho pro-liferative disease of cattle and in many human cancers. Overexpression of the CK2 α catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2). The activity values were directly correlated with the protein expression level of the CK2α (catalytic subunit). The α subunit is only detected in brain and testicles. By contrast, Northern blot analyses of the CK2 α mRNA shows the strongest signals to be present in brain, liver, heart and lung. In kidney, spleen and testicles mRNAs is only weakly detectable. ICBP90, a transcription factor exhibiting antiapoptotic property, has several putative CK2 phosphorylation sites. ICBP90 is more efficiently phosphorylated by the free CK2 α subunit than by the heterotetrameric CK2 (α, β) (3). Thus, CK2 α is an important regulator of the transcriptional activity of ICBP90 and therefore of the antiapoptotic properties of ICBP90.

序列

CK2a1蛋白,有活性的蛋白产品，又称Ck2a1.其对应NCBI基因号为9261，NCBI基因别称为MAPKAPK2源，对应Accession号为P49137.该蛋白产品又称Active CK2a1, CK2a1, CK2alpha1, CK2, human CK2a1, active kinase, active kinases, recombinant CK2a1, recombinant CK2, kinase activity assay, protein kinase 等.

来源宿主

提供的【CK2a1】CK2a1蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.

溶解建议

提供的CK2a1蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.

保存建议

在您收到艾美捷发出的【CK2a1】CK2a1蛋白,有活性的产品后，建议将其置于-80°C保存.

其他

BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的Leader，BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供优质、新的细胞生物学研究工具而不断扩大产品及服务质量.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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