Mn（III）TMPyP is a manganese-porphyrin which acts as a superoxide dismutase （SOD） mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical （O2-）. Mn（III）TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M-1s-1 and ~2 x 106 M-1s-1， respectively. Mn（III）TMPyP protected and enhanced the growth of SOD null E. coli with a doubling time of 60 minutes （as compared to 240 minutes of the control） at 25 uM.
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Mn（III）TMPyP is a cell-permeable SOD mimic and peroxynitrite decomposition catalyst.{6039} The rate constants for superoxide dismutation and peroxynitrite decomposition are 3.9 x 10^7 M-1s-1 and ~2 x 10^6 M-1s-1， respectively.{6039，4009}
