Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides， .omega.-1 and .omega.-hydroxylated compounds via what is known as the epoxidase pathway. PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. PPOH inhibits the formation of arachidonate 11，12 epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 of 9 uM， but has effect on the formation of 20-HETE， the .omega.-hydroxylation product of CYP4A1.
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Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides， .omega.-1 and .omega.-hydroxylated compounds via what is known as the epoxidase pathway.{313，403，823} PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.{8589} PPOH inhibits the formation of arachidonate 11，12 epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 9 uM， but has effect on the formation of 20-HETE， the .omega.-hydroxylation product of CYP4A1.{8588}
