- 中文名称
【SIRT1】重组人SIRT1（193-747 aa）（带GST标签）（50个单位）
- 英文名字
- SIRT1 (193-747 aa) (GST-tagged), Human recombinant
- 供应商
- Biovision
- 产品货号
- 7264-50
- 产品报价
- ￥已停产
- 产品说明书
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- 产品新闻
- 背景资料
- The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-7. SIRT1, which is located in the nucleus, is the human sirtuin with the greatest homology to yeast Sir2 (Silent information regulator 2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. These results have significant implications regarding an important role of SIRT1 in modulating the sensitivity of cells in the p53-dependent apoptotic response and the possible effect in cancer therapy. Since the growth suppressive function of p53 is strongly enhanced by DNA damaging reagents, it is expected that inhibitors of SIRT1 may be effective anti-cancer drugs.
- 序列
- 重组人SIRT1 (193-747 aa) (带GST标签)蛋白产品，又称NAD-dependent Deacetylase 1, SIR2L1, SIR2-like Protein 1, Sirtuin 1, Silent Information Regulator 2.其对应NCBI基因号为23411，对应Accession号为Q96EB6.
- 来源宿主
- 提供的【SIRT1】重组人SIRT1 (193-747 aa) (带GST标签)产品的来源为大肠杆菌重组表达.
- 溶解建议
- 重组人SIRT1 (193-747 aa) (带GST标签)产品为液体即用型，其溶液组成为：Supplied as a solution in 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol
- 保存建议
- 在您收到艾美捷发出的【SIRT1】重组人SIRT1 (193-747 aa) (带GST标签)产品后，建议将其置于-80°C保存.
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的Leader，BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供优质、新的细胞生物学研究工具而不断扩大产品及服务质量.
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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