The pro-angiogenic factor HIF-1.alpha. is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-.alpha. prolyl hydroxylase (HIF-PH). 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor .alpha.-keto glutarate, with effective concentrations in the low uM range. 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1.alpha. system.
产品描述
A cell permeable, competitive inhibitor of HIF-PH with effective concentrations in the low uM range