The Cayman ChemicalPPARγ Ligand Pack contains a combination of frequently used ligands for the nuclear PPAR.gamma.. Each kit contains Ciglitazone， the first characterized member of the thiazolidinedione （TZD） class that binds to the PPAR.gamma. ligand-binding domain with an EC50 value of 3.0 uM. Rosiglitazone， a key reference TZD also called BRL 49653， is another PPAR.gamma. agonist provided. Also included is Troglitazone （ResulinTM）， another TZD； it was withdrawn from human therapeutic use due to hepatotoxicity. Also in this assortment is 15-deoxy-.DELTA.12，14-Prostaglandin J2， a potent PPAR.gamma. ligand derived from PGD2. The actions of all of these compounds can be antagonized by the selective PPAR.gamma. antagonist， GW 9662， which is also in the kit.
产品描述
The Cayman ChemicalPPARγ Ligand Pack contains a combination of frequently used ligands for the nuclear PPAR.gamma.. Each kit contains Ciglitazone， the first characterized member of the thiazolidinedione （TZD） class that binds to the PPAR.gamma. ligand-binding domain with an EC50 value of 3.0 uM.{7575，10122} Rosiglitazone， a key reference TZD also called BRL 49653， is another PPAR.gamma. agonist provided. Also included is Troglitazone （ResulinTM）， another TZD； it was withdrawn from human therapeutic use due to hepatotoxicity.{8555} Also in this assortment is 15-deoxy-.DELTA.12，14-PGJ2， a potent PPAR.gamma. ligand derived from PGD2. The actions of all of these compounds can be antagonized by the selective PPAR.gamma. antagonist， GW 9662，{9318} which is also in the kit.
