Catechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves， grape seeds， and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or .alpha.-tocopherol in certain in vitro assays of lipid peroxidation. Catechin inhibits the free radical-induced oxidation of isolated LDL by AAPH. It has also been reported to act as an inhibitor of COX-1 with an IC50 of about 80 uM. Catechin and other related procyanidin compounds have antitumor activity when tested in a two-stage mouse epidermal carcinoma model employing topical application.
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Catechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves， grape seeds， and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or .alpha.-tocopherol in certain in vitro lipid peroxidation assays.{7582} Catechin inhibits the free radical-induced oxidation of isolated LDL by AAPH.{7442} It has also been reported to act as an inhibitor of COX-1 with an IC50 value of about 80 uM.{8140} Catechin and other related procyanidin compounds have antitumor activity when tested in a two-stage mouse epidermal carcinoma model employing topical application.{7582}
