PPAR.gamma. is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis. Ligands for PPAR.gamma. include antidiabetic drugs of the thiazolidinedione structural class， 15-deoxy-.DELTA.12，14-prostaglandin J2， and NSAIDS. BADGE is a synthetic compound used in the production of polycarbonate and industrial plastics. This compound was recently identified as an antagonist of PPAR.gamma.. BADGE binds to PPAR.gamma. with an apparent Kd of 100 uM and interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.
产品描述
PPAR.gamma. is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis.{6619，2160，6620，4136} Ligands for PPAR.gamma. include antidiabetic drugs of the thiazolidinedione structural class， 15-deoxy-.DELTA.12，14-PGJ2， and NSAIDS.{8461，7575，1424，4044} BADGE is a synthetic compound used in the production of polycarbonate and industrial plastics. This compound was recently identified as an antagonist of PPAR.gamma..{8241} BADGE binds to PPAR.gamma. with an apparent Kd of 100 uM and interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.{8241}
