中文名称

CAY10416 (50 mg)

英文名字

CAY10416, 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole

供应商

Cayman

产品货号

70635-50

产品报价

￥21070/50 mg

产品说明书

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产品新闻

背景资料

Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 uM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC50 value of 83 uM.

产品描述

CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively.{10003} The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 uM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC50 value of 83 uM.

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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