Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET)-1 to the ETA receptor in A10 cells at 0.1 μM.{1209} Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 μM, which suggests its usefulness as an antiangiogenic agent.{25064}
产品描述
An antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor ET-1 to the ETA receptor in A10 cells at 0.1 μM; also inhibits VEGF-induced tube formation of HUVECs at 3-10 μM